Molecular Immunology Lab
Their research focuses on immunology, with a particular interest in myeloid cells and the molecular mechanisms driving their functional plasticity in cancer and immune-mediated diseases, including inflammatory bowel disease.
In recent years, the group has specialized in malignant pleural mesothelioma (MPM), an aggressive thoracic cancer.
Although MPM is highly resistant to conventional therapies, immune checkpoint blockade (ICB) has emerged as a promising therapeutic strategy. Building on this breakthrough and their recent findings, the team’s current projects aim to identify novel combination immunotherapies to enhance anti-tumor immunity, using human multicellular spheroid models and murine orthotopic MPM models.
Parallel efforts focus on uncovering predictive biomarkers of ICB response through systematic analysis of tumor tissue and liquid biopsies from MPM patients.
Keywords
Macrophages; Tumor microenvironment; Mesothelioma; Cancer; Inflammatory disorders.
GROUP MEMBERS
Chiara Porta
Group Leader
Associate Professor
Martina Delsignore
PhD Student
Gaia Cassinari
PhD Student
Simona Revello
Research Fellow
For any information, please contact
corefacilities.ipazia@uniupo.it
or segreteria.caad@uniupo.
CAAD
Center for Translational Research on
Autoimmune and Allergic Disease
Centro di Ricerca Traslazionale
sulle Malattie Autoimmuni e Allergiche
Corso Trieste 15/A
Novara – 28100 (ITALY)
Molecular Immunology Lab
Their research focuses on immunology, with a particular interest in myeloid cells and the molecular mechanisms driving their functional plasticity in cancer and immune-mediated diseases, including inflammatory bowel disease.
Keywords
Macrophages; Tumor microenvironment; Mesothelioma; Cancer; Inflammatory disorders.
In recent years, the group has specialized in malignant pleural mesothelioma (MPM), an aggressive thoracic cancer.
Although MPM is highly resistant to conventional therapies, immune checkpoint blockade (ICB) has emerged as a promising therapeutic strategy. Building on this breakthrough and their recent findings, the team’s current projects aim to identify novel combination immunotherapies to enhance anti-tumor immunity, using human multicellular spheroid models and murine orthotopic MPM models.
Parallel efforts focus on uncovering predictive biomarkers of ICB response through systematic analysis of tumor tissue and liquid biopsies from MPM patients.
GROUP MEMBERS
Chiara Porta
Group Leader
Associate Professor
Martina Delsignore
PhD Student
Gaia Cassinari
PhD Student
Simona Revello
Research Fellow
For any information, please contact
corefacilities.ipazia@uniupo.it
or segreteria.caad@uniupo.
CAAD
Center for Translational Research on
Autoimmune and Allergic Disease
Centro di Ricerca Traslazionale
sulle Malattie Autoimmuni e Allergiche
Corso Trieste 15/A
Novara – 28100 (ITALY)