Cell Stress & Death Lab
The Cell Stress & Death Lab investigates the molecular mechanisms of ferroptosis — a newly characterized, iron-dependent form of regulated cell death—and its critical interplay with Endoplasmic Reticulum (ER) Stress. It plays a central role in numerous diseases, including cancer, stroke, metabolic and neurodegenerative disorders.
Keywords
Cell Death – Ferroptosis; ER Stress & UPR; Cancer; Autoimmune Diseases
This research explores the molecular mechanism of ferroptosis, how it contributes to disease pathogenesis and how it is influenced by ER stress and the Unfolded Protein Response (UPR).
The Group is particularly interested in how dysregulation of ferroptosis and ER stress pathways drives disease progression, shapes the cellular response to therapy, and influences long-term tissue function. Understanding these interactions could uncover new biomarkers and therapeutic targets for treating stress-related diseases.
To dissect these complex cellular processes, the lab utilizes:
- in vitro models to analyze molecular mechanisms (2D & 3D)
- ex vivo systems for studying tissue-level dynamics (e.g., GEVS)
- in vivo animal models to understand physiological outcomes.
This integrated approach allows to capture a comprehensive view of how ferroptosis and ER stress operate in both healthy and diseased states.
By advancing knowledge of these interconnected stress pathways, the Group aims to develop novel strategies for manipulating cell death in a controlled way — offering potential breakthroughs in the treatment of diseases driven by cellular dysfunction.
GROUP MEMBERS
Marco Corazzari
Group Leader
Full Professor
Mara Gagliardi
Researcher (RTDa)
Romina Monzani
Post Doc Research fellow
Emanuele Ferrario
PhD Student
For any information, please contact
corefacilities.ipazia@uniupo.it
or segreteria.caad@uniupo.
CAAD
Center for Translational Research on
Autoimmune and Allergic Disease
Centro di Ricerca Traslazionale
sulle Malattie Autoimmuni e Allergiche
Corso Trieste 15/A
Novara – 28100 (ITALY)
Cell Stress & Death Lab
The Cell Stress & Death Lab investigates the molecular mechanisms of ferroptosis — a newly characterized, iron-dependent form of regulated cell death—and its critical interplay with Endoplasmic Reticulum (ER) Stress. It plays a central role in numerous diseases, including cancer, stroke, metabolic and neurodegenerative disorders.
Keywords
Cell Death – Ferroptosis; ER Stress & UPR; Cancer; Autoimmune Diseases
This research explores the molecular mechanism of ferroptosis, how it contributes to disease pathogenesis and how it is influenced by ER stress and the Unfolded Protein Response (UPR).
The Group is particularly interested in how dysregulation of ferroptosis and ER stress pathways drives disease progression, shapes the cellular response to therapy, and influences long-term tissue function. Understanding these interactions could uncover new biomarkers and therapeutic targets for treating stress-related diseases.
To dissect these complex cellular processes, the lab utilizes:
- in vitro models to analyze molecular mechanisms (2D & 3D)
- ex vivo systems for studying tissue-level dynamics (e.g., GEVS)
- in vivo animal models to understand physiological outcomes.
This integrated approach allows to capture a comprehensive view of how ferroptosis and ER stress operate in both healthy and diseased states.
By advancing knowledge of these interconnected stress pathways, the Group aims to develop novel strategies for manipulating cell death in a controlled way — offering potential breakthroughs in the treatment of diseases driven by cellular dysfunction.
GROUP MEMBERS
Marco Corazzari
Group Leader
Full Professor
Mara Gagliardi
Researcher (RTDa)
Romina Monzani
Post Doc Research fellow
Emanuele Ferrario
PhD Student
For any information, please contact
corefacilities.ipazia@uniupo.it
or segreteria.caad@uniupo.
CAAD
Center for Translational Research on
Autoimmune and Allergic Disease
Centro di Ricerca Traslazionale
sulle Malattie Autoimmuni e Allergiche
Corso Trieste 15/A
Novara – 28100 (ITALY)